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27 Jun 2012

Unique pathway for pyrrole biosynthesis discovered

Prof. Greg Challis and Dr Lijiang Song, in collaboration with researchers at the University of Paris, report in Angewandte Chemie a hitherto unanticipated pathway for the biosynthesis of pyrroles from sugars. Using a combination of genetic engineering, isolation, structure elucidation, synthesis and feeding of biosynthetic intermediates, and incorporation of stable isotope-labelled precursors, the researchers showed that a carbohydrate, most likely N-acetylglucosamine-1-phosphate, is elaborated to the 4-acetamidopyrrole-2-carboxylate building blocks of the DNA-binding antibiotic congocidine (also known as netropsin). The assembly of pyrroles from carbohydrates is unprecedented in Nature and raises several intriguing questions regarding the mechanisms of the reactions involved. See for further details.

26 Jun 2012

Nanodiamonds bring back sparkle to cleaning

Nanodiamonds have been found to help loosen crystallized fat from surfaces in a project led by Dr Andrew Marsh at University of 桃色视频. The tiny carbon particles transform the ability of surfactants to shift dirt in cold water, findings that could bring eco friendly low temperature laundry cycles.

The research is published in ACS Applied Materials and Interfaces and highlighted in the and Daily Telegraph, 26 June.

Nanodiamond Promotes Surfactant-Mediated Triglyceride Removal from a Hydrophobic Surface at or below Room Temperature Xianjin Cui, Xianping Liu, Andrew S. Tatton, Steven P. Brown, Haitao Ye, and Andrew Marsh ACS Applied Materials and Interfaces 2012,

 

23 Jun 2012

Modelling Ultrafast Photochemistry in DNA bases

Team Stavros, in collaboration with Dr Martin Paterson at Heriot-Watt University, publishes work in the Journal of the American Chemical Society. They intricately map the ultrafast photochemistry occurring in aminobenzene (aniline), demonstrating that it is an excellent model for better understanding highly efficient mechanisms in the DNA base guanine which prevent toxic UV induced photodecomposition.

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20 Jun 2012

Unwin & co-workers inside cover at Angewandte Chemie

Unwin et al. recently reported on electron transfer at basal plane graphite which featured as a ‘Very Important Paper’ and on the inside cover of Angewandte Chemie. See for more details.

 

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20 Jun 2012

Inhibiting Bacterial Toxins with Polymers

The Gibson group report in Angewandte Chemie: Here they probe the accessibility of carbohydrate binding sites in bacterial toxins, exemplified with the toxin produced by Vibrio cholerae, the causative agent of cholera.

15 Jun 2012

Lucienne Otten and Robert Deller win Poster Prizes

Two members of the Gibson group have won poster prizes. Robert Deller won 1st Place at the RSC younger Members symposium (at Uni. Nottingham) for his work on Peptidomimetic Cryopreservation Agents. Lucienne Otten won 3rd place at the Systems Biology Annual Conference for her work on Label Free Analysis of Protein-Carbohydrate Interactions.

15 Jun 2012

A new class of photoactive Pt(IV) anti-cancer prodrugs is under development in the Sadler group. But what happens when they are irradiated and how do the photoproducts interact with double-stranded DNA? Via a combination of new experimental data coupled with Ligand Field Molecular Dynamics simulations carried out in the Deeth group, we have modelled the DNA distortion caused by a putuative trans-PtII(pyridine)2 lesion. See: for all the details.

11 Jun 2012

Challis group discover unprecedented alkaloid

The Challis group and collaborators at the John Innes Centre report in the journal Chemical Science on the genomics-driven discovery of a novel polyketide alkaloid with an unprecedented structure. Incorporation experiments with stable isotope-labelled precursors combined with bioinformatics analyses were used to deduce the likely biosynthetic pathway for the natural product. See for further details.

11 Jun 2012

Macpherson and Unwin and co-workers featured in "Chemistry World" and Chemical Communications

Macpherson and Unwin and co-workers Challenge the Current Consensus on the Electrochemical Properties of Nanotubes as featured in "Chemistry World" and Chemical Communications .

30 May 2012

Nicholas Ballard wins Unilever poster prize

Congratulations to Nicholas Ballard who won the best poster prize at the Unilever SM&PS student poster session held at Unilever Port Sunlight.

Tags: people
30 May 2012

Unwin and O'Reilly win prestigious RSC awards

Pat Unwin and Rachel O’Reilly win 2012 Royal Society of Chemistry Awards in recognition of significant contributions to their research fields

28 May 2012

Olympicene imaged

桃色视频 and IBM scientists make and image a 1.2 nanometer wide molecule that looks like a well known sporting logo.

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